Policlinico San Donato Research Hospital

The Policlinico San Donato Research Hospital is the largest and most renowned Italian center specialized in the field of cardiovascular treatments. The hospital is accredited by the Italian National Health Service (SSN) and is home to the Degree Course in Medicine and Surgery, in collaboration with the Università degli Studi di Milano.

Founded in 1969 and extending over 50,000 square meters in the south-eastern part of Milan, the multi-specialty healthcare institution is a leader in Italy and among best centers in Europe as for the amount as well as for the complexity of performed cardiac surgery and interventional cardiology procedures in children (> 1,000 procedures per year) and adult patients (> 1,000 surgical interventions and 6,000 interventional cardiology procedures). The San Donato’s Arrhythmology and Electrophysiology Unit delivers one of the highest numbers of cardiac ablations in the world (> 1,400 per year). San Donato has a research center aimed at studying of the heart and blood vessels in adults and children and searching of new prevention and treatment methods that has been recognized by the Italian Ministry of Health as a Scientific Institute for Research, Hospitalization and Health Care (IRCCS). Policlinico San Donato is a pioneer of international cooperation and a founder of charity missions for the treatment of children with congenital heart diseases that are run in collaboration with the association “Bambini Cardiopatici nel Mondo”. Thanks to this project more than 3,000 children all over the world have received their treatment.

The Department of Radiology of the Policlinico San Donato is a unit including 12 radiologists, 26 technicians/radiographers, and 10 nurses. The department is equipped with cutting edge technology, including 3 radiology rooms, 3 multislice computed tomography (CT), 2 magnetic resonance (MRI), 4 ultrasound, and 2 mammography units. The diagnostic workflow is organized according to well differentiated subspecialty areas, each of them under the responsibility of a certified radiologist. The clinical activity benefits from a relevant work of advanced research in several fields of radiology, as testified by the high number of scientific publications every year: over 270 papers available on the PubMed in the last ten years for a total impact factor of 885, with 55 articles in 2020 and 43 articles in 2021 up to October 14, 2021. Research areas of major interest: Breast; Cardiovascular, Brain, Body, Musculoskeletal.

Role of institution in the project

T1.4: PSD will link EUCAIM to CHAIMELEON project by ensuring all technical and legal requirements.

WP5: PSD will contribute to the definition of the Common-Data-Model for imaging data, protocols, formats and terminologies. In collaboration with subcontractor DeepTrace Technologies, PSD will develop data cleaning tools for data quality, in particular for deleting annotations on images (eg US). Moreover, PSD will develop tools for harmonizing imaging data with respect to acquisition systems.

T7.2: PSD will contribute in formulating research questions and defining use cases to demonstrate and validate the platform’s usability in secondary use of data in the field of breast cancer.

Francesco Sardanelli

Francesco Sardanelli is full professor of radiology and faculty member of the PhD course in Translational Medicine at Università degli Studi di Milano, director of Department of Radiology at Research Hospital (IRCCS) Policlinico San Donato, director of the European Network Assessment of Imaging in Medicine, joint initiative of the European Institute for Biomedical Imaging Research. Previously member of the Editorial Board of Eur Radiol, Radiol Med, Breast, Am J Roentgenol, Insights Imaging, Clin Transl Imaging, is currently the Editor-in-Chief of Eur Radiol Exp. Reviewer for over 60 medical journals, in 2021 has been awarded with the Platinum Level Reviewer Lifetime Achievement by Am J Roentgenol. He held over 400 invited talks, published 8 books and 57 book chapter. Scopus metrics: 474 documents; 12,038 citations; h-index 55, and over 500 full articles. Previous roles: member, Research Committee, European Society of Radiology (ESR); member, National Council, Società Italiana di Radiologia Medica (SIRM); president, Italian College of Breast Radiologists by SIRM; co-founder, Breast Centres Certification; president, European Society of Breast Imaging. Honors: Gold Medal 2021 of the European Society of Radiology; Gold Medal 2023 European Society of Breast Imaging. Honorary memberships: Royal College of Breast Radiologists, United Kingdom, 2009; Iranian Society of Radiology, 2014.

Giovanni Di Leo

Giovanni Di Leo has a recognized expertise in clinical evidence-based research methodology and biostatistics applied to medical imaging, in accordance with GCPs and ICH. Coordinator of research activity at the Radiology Unit of the IRCCS Policlinico San Donato (San Donato Milanese, Italy). As such, they have leaded the designing, conduction and writing of dozens of projects, participated in scientific exchange and engagement with the medical community and stakeholders. This led to publication of 119 articles, 2 books, 4 book chapters and several invited speeches to radiological congresses. h-index 22 (1764 citations). They are a member of the EuroAIM (European Network for the Assessment of Imaging in Medicine, joint initiative of the European Institute for Biomedical Imaging Research, Vienna - Austria) as project manager. They are coordinating an international prospective multi-center individual patient data meta-analysis sponsored by Bayer (Berlin, Germany) in collaboration with the University of Sidney, that has a target sample of 7000 breast cancer patients. They are also coordinating the research activities at the Radiology Unit of IRCCS Policlinico San Donato within the CHAIMELEON project, that was funded by the HORIZON2020 with 8.7M.

Anna Colarieti

Anna Colarieti is a highly skilled Radiologist and qualified Researcher in medical imaging with a special interest in breast and urogenital imaging. Coordinator of clinical activity in body MR at IRCCS Policlinico San Donato (San Donato Milanese, Italy). Since 2016, they have collaborated in several research projects. In 2021, they were a research fellow at the University of Cambridge, UK, with professor Tristan Barrett’ s group (prostate cancer) and Professor Fiona Gilbert’s group (breast cancer). In the last year, they have focused their research on Artificial Intelligence (AI) applied in the prostate cancer and in the breast imaging. This led to publication of 25 articles, and several invited speeches to radiological meetings; h-index 10 with 460 citations. They are an active member of the European Network for Assessment of Imaging in Medicine (EuroAIM), a joint initiative of the European Institute for Biomedical Imaging Research (EIBIR), a research platform of the European Society of Radiology. In particular, they are a member of the EuroAIM Working Group on Evidence-Based Radiology with special focus on pelvic MRI (multiparametric prostate MRI and dynamic MR-defecography). They are also board member of the Ultrasound section of SIRM (Società Italiana di Radiologia medica ed interventistica).

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